From world-class luxury lodges to charming boutique hotels — handpicked stays across the continent.
⭐ Featured
Explora Atacama is an all-inclusive desert lodge built around a restored 18th-century adobe hacienda, with rates covering all meal...
A simple, well-run adobe guesthouse two blocks from San Pedro's main plaza, popular with backpackers organising their own tours an...
Compare More Options
Browse thousands of hotels, guesthouses and hostels across South America on Expedia.
Patagonia and Galápagos lodges sell out months in advance. Book as early as possible for peak season.
April–May and September–October offer lower rates and fewer crowds at most destinations.
Always compare Expedia, the hotel's own site, and specialist agents — rates vary significantly.