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Hotels in South America

From world-class luxury lodges to charming boutique hotels — handpicked stays across the continent.

Belmond Copacabana Palace ⭐ Featured
Belmond Copacabana Palace LUXURY · ★★★★★ · RIO DE JANEIRO

The Copacabana Palace is Rio's most legendary hotel, a gleaming white Art Deco palace that has graced the Copacabana beachfront si...

Beachfront rooftop pool Cipriani fine dining restaurant Full-service spa Fitness centre Concierge service
$680 /night
📍 Rio de Janeiro
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Inkaterra Machu Picchu Pueblo Hotel ⭐ Featured
Inkaterra Machu Picchu Pueblo Hotel LUXURY · ★★★★★ · MACHU PICCHU

Nestled within a cloud forest just minutes from Machu Picchu, the Inkaterra Pueblo Hotel is a collection of whitewashed casitas se...

Cloud forest nature trails Andean botanical spa Gourmet Peruvian restaurant Orchid garden Guided birdwatching
$520 /night
📍 Machu Picchu
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explora Patagonia ⭐ Featured
explora Patagonia LUXURY · ★★★★★ · PATAGONIA

explora Patagonia is one of the world's great wilderness lodges, perched above the turquoise waters of Lake Pehoé with a direct v...

All-inclusive rates Unlimited guided excursions Heated indoor pool Spa and massage Gourmet restaurant
$890 /night
📍 Patagonia
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Belmond Sanctuary Lodge ⭐ Featured
Belmond Sanctuary Lodge LUXURY · ★★★★★ · MACHU PICCHU

The only hotel at the gates of Machu Picchu — the Belmond Sanctuary Lodge is located metres from the site entrance, giving guest...

Only hotel at Machu Picchu gates Early site access before crowds Gourmet restaurant with mountain views Spa and infinity plunge pools Guided Machu Picchu excursions
$720 /night
📍 Machu Picchu
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Hotel Casa San Agustín ⭐ Featured
Hotel Casa San Agustín LUXURY · ★★★★★ · CARTAGENA

Housed in a lovingly restored 18th-century colonial mansion within the walled city, Casa San Agustín is Cartagena's most intimate...

Three courtyard pools Rooftop terrace bar Colonial architecture Gourmet restaurant Spa treatments
$350 /night
📍 Cartagena
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Awasi Patagonia
Awasi Patagonia LUXURY · ★★★★★ · TORRES DEL PAINE

The most exclusive lodge in Patagonia — just 12 private villas set in a nature reserve adjacent to Torres del Paine National Par...

12 private villas with dedicated guide and 4x4 Bespoke daily excursion programme Puma tracking with expert guides Outstanding restaurant Spa and treatments
$1,200 /night
📍 Torres del Paine
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Awasi Iguazú
Awasi Iguazú LUXURY · ★★★★★ · IGUAZU FALLS

Awasi Iguazú is an exclusive lodge of just 14 private villas set within a private nature reserve bordering Iguazú National Park....

Private villa with plunge pool Personal guide and 4x4 Private nature reserve access Gourmet restaurant Wildlife spotting walks
$780 /night
📍 Iguazu Falls
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Singular Patagonia
Singular Patagonia LUXURY · ★★★★★ · PATAGONIA

A converted 1915 cold-storage plant transformed into one of Patagonia's most celebrated hotels. The Singular sits on a private pie...

Industrial heritage architecture Waterfront pier location Spa and heated pool Outstanding restaurant Guided park excursions
$650 /night
📍 Patagonia
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Inkaterra Reserva Amazónica
Inkaterra Reserva Amazónica LUXURY · ★★★★★ · AMAZON RAINFOREST

One of the most decorated eco-lodges in the Amazon — a collection of 35 casitas on the Madre de Dios river within the Tambopata ...

35 riverside casitas in national reserve Canopy towers and walkway Giant otter and macaw clay lick All-inclusive with expert guides Conservation and research programmes
$420 /night
📍 Amazon Rainforest
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Hotel Sofitel Legend Santa Clara
Hotel Sofitel Legend Santa Clara LUXURY · ★★★★★ · CARTAGENA

A 17th-century convent transformed into Cartagena's grandest hotel — the former cells of Dominican nuns now occupy beautifully a...

Colonial convent architecture Courtyard pool in former convent garden 1621 fine dining restaurant Spa in original vaulted chambers Outdoor terrace bar
$310 /night
📍 Cartagena
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Gran Meliá Iguazú
Gran Meliá Iguazú LUXURY · ★★★★★ · IGUAZU FALLS

The only hotel inside Argentine Iguazú National Park — guests wake to the sound of the falls and can access the park before it ...

Only hotel inside Argentine National Park Pre-opening falls access Infinity pool overlooking jungle Nandutí restaurant with falls view Guided private park excursions
$380 /night
📍 Iguazu Falls
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Palacio Duhau Park Hyatt Buenos Aires
Palacio Duhau Park Hyatt Buenos Aires LUXURY · ★★★★★ · BUENOS AIRES

The Palacio Duhau Park Hyatt occupies a magnificent early 20th-century French-style palace in the exclusive Recoleta neighbourhood...

Award-winning wine bar Luxury spa Garden terrace Fine dining restaurant Indoor pool
$480 /night
📍 Buenos Aires
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Hotel das Cataratas — Belmond
Hotel das Cataratas — Belmond LUXURY · ★★★★★ · IGUAZU FALLS

The Brazilian counterpart to early-morning privilege — the only hotel inside the Brazilian Iguaçu National Park. A pink colonia...

Only hotel inside Brazilian National Park Pre-opening waterfall walkway access Colonial architecture and tropical gardens Itaipu restaurant Swimming pool and spa
$450 /night
📍 Iguazu Falls
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Pikaia Lodge
Pikaia Lodge LUXURY · ★★★★★ · GALáPAGOS ISLANDS

The finest land-based hotel in the Galápagos — a design-led lodge on 400 acres of private ranch on Santa Cruz, with wild giant ...

Private yacht for island excursions Wild giant tortoises on property Rooftop infinity pool Bespoke My Galápagos itinerary Expert naturalist guides
$890 /night
📍 Galápagos Islands
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Browse thousands of hotels, guesthouses and hostels across South America on Booking.com.

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How to Find the Best Deal

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Book Early

Patagonia and Galápagos lodges sell out months in advance. Book as early as possible for peak season.

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Travel Shoulder Season

April–May and September–October offer lower rates and fewer crowds at most destinations.

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Compare Rates

Always compare Booking.com, the hotel's own site, and specialist agents — rates vary significantly.