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Hotels in South America

From world-class luxury lodges to charming boutique hotels — handpicked stays across the continent.

Tierra Viva Cusco Saphi
Tierra Viva Cusco Saphi BOUTIQUE · ★★★★ · MACHU PICCHU

A warmly decorated boutique hotel in the San Blas neighbourhood — Cusco's most charming district of narrow colonial lanes and ar...

Included buffet breakfast Rooftop terrace with plaza views Colonial building with Andean decor 24-hour concierge Airport and train transfers
$95 /night
📍 Machu Picchu
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EcoCamp Patagonia
EcoCamp Patagonia BOUTIQUE · ★★★★ · PATAGONIA

EcoCamp Patagonia pioneered sustainable dome accommodation inside Torres del Paine National Park. Geodesic domes with transparent ...

In-park location with tower views All-inclusive guided excursions Geodesic dome accommodation Restaurant and communal dome Sustainable energy systems
$580 /night
📍 Patagonia
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Treehouse Lodge
Treehouse Lodge BOUTIQUE · ★★★★ · AMAZON RAINFOREST

Six extraordinary treehouses built 10–35m above the Amazon forest floor — the only way to sleep in the rainforest canopy. Acce...

Canopy treehouses 10–35m high Only accessible by boat All-inclusive meals and excursions Canopy walkway system Expert naturalist guides
$380 /night
📍 Amazon Rainforest
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Tcherassi Hotel & Spa
Tcherassi Hotel & Spa BOUTIQUE · ★★★★★ · CARTAGENA

Colombian fashion designer Silvia Tcherassi's exquisitely curated boutique hotel within the walled city. Six interconnected coloni...

Rooftop pool with old city views Designer interiors by Silvia Tcherassi Restaurant with Caribbean cuisine Spa treatments Concierge and private tours
$420 /night
📍 Cartagena
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Lago Grey Hotel
Lago Grey Hotel BOUTIQUE · ★★★★ · TORRES DEL PAINE

The most dramatically positioned mid-range option in Torres del Paine — a floating hotel complex on Lago Grey, with icebergs fro...

Direct Grey Glacier views from rooms Floating hotel on Lago Grey Grey Glacier boat departure point adjacent Restaurant with iceberg views In-park location
$290 /night
📍 Torres del Paine
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Finch Bay Eco Hotel
Finch Bay Eco Hotel BOUTIQUE · ★★★★ · GALáPAGOS ISLANDS

The Finch Bay Eco Hotel is the only hotel on Santa Cruz Island with direct beach access, and its commitment to ecological sustaina...

Private beach access Eco-certified operations Yacht excursions Organic garden restaurant Naturalist guides
$420 /night
📍 Galápagos Islands
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Scalesia Lodge
Scalesia Lodge BOUTIQUE · ★★★★ · GALáPAGOS ISLANDS

An intimate boutique lodge in the highlands of Santa Cruz — set within scalesia forest, the endemic cloud forest of the Galápag...

Giant tortoises freely on property Endemic scalesia forest setting Naturalist guided excursions Restaurant with local ingredients Snorkelling and diving arranged
$340 /night
📍 Galápagos Islands
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Casa Cavia
Casa Cavia BOUTIQUE · ★★★★★ · BUENOS AIRES

One of Buenos Aires' finest boutique hotels — a 1927 mansion in the exclusive Palermo Chico neighbourhood that has been transfor...

6 rooms only — completely personal service La Mérienda bookshop-café-restaurant 1927 mansion architecture Palermo Chico residential neighbourhood Curated book and art collection
$320 /night
📍 Buenos Aires
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Santa Teresa Hotel RJ — MGallery
Santa Teresa Hotel RJ — MGallery BOUTIQUE · ★★★★★ · RIO DE JANEIRO

A legendary bohemian retreat set in a restored 1850s mansion on the hillside cobblestones of Santa Teresa. This MGallery property ...

Rooftop pool with city panorama Espirito Santa restaurant Art gallery throughout Spa and wellness Concierge and tours
$280 /night
📍 Rio de Janeiro
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Mine Hotel Boutique
Mine Hotel Boutique BOUTIQUE · ★★★★ · BUENOS AIRES

A charming boutique hotel in the heart of Palermo Soho — the epicentre of Buenos Aires' design, dining, and nightlife scene. Min...

Outdoor pool and terrace Excellent included breakfast Palermo Soho location Warm Argentine service Walking distance to top restaurants
$180 /night
📍 Buenos Aires
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Yoo2 Rio de Janeiro
Yoo2 Rio de Janeiro BOUTIQUE · ★★★★ · RIO DE JANEIRO

A design-forward boutique hotel in the hip Botafogo neighbourhood — the neighbourhood where young Cariocas actually live. The ro...

Rooftop pool with Sugarloaf views Rooftop bar and restaurant Fitness centre Metro access 24-hour room service
$165 /night
📍 Rio de Janeiro
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Browse thousands of hotels, guesthouses and hostels across South America on Booking.com.

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How to Find the Best Deal

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Book Early

Patagonia and Galápagos lodges sell out months in advance. Book as early as possible for peak season.

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Travel Shoulder Season

April–May and September–October offer lower rates and fewer crowds at most destinations.

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Compare Rates

Always compare Booking.com, the hotel's own site, and specialist agents — rates vary significantly.