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Hotels in South America

From world-class luxury lodges to charming boutique hotels — handpicked stays across the continent.

Hotel Casa San Agustín ⭐ Featured
Hotel Casa San Agustín LUXURY · ★★★★★ · CARTAGENA

Housed in a lovingly restored 18th-century colonial mansion within the walled city, Casa San Agustín is Cartagena's most intimate...

Three courtyard pools Rooftop terrace bar Colonial architecture Gourmet restaurant Spa treatments
$350 /night
📍 Cartagena
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Tcherassi Hotel & Spa
Tcherassi Hotel & Spa BOUTIQUE · ★★★★★ · CARTAGENA

Colombian fashion designer Silvia Tcherassi's exquisitely curated boutique hotel within the walled city. Six interconnected coloni...

Rooftop pool with old city views Designer interiors by Silvia Tcherassi Restaurant with Caribbean cuisine Spa treatments Concierge and private tours
$420 /night
📍 Cartagena
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Hotel Sofitel Legend Santa Clara
Hotel Sofitel Legend Santa Clara LUXURY · ★★★★★ · CARTAGENA

A 17th-century convent transformed into Cartagena's grandest hotel — the former cells of Dominican nuns now occupy beautifully a...

Colonial convent architecture Courtyard pool in former convent garden 1621 fine dining restaurant Spa in original vaulted chambers Outdoor terrace bar
$310 /night
📍 Cartagena
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Browse thousands of hotels, guesthouses and hostels across South America on Booking.com.

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How to Find the Best Deal

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Book Early

Patagonia and Galápagos lodges sell out months in advance. Book as early as possible for peak season.

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Travel Shoulder Season

April–May and September–October offer lower rates and fewer crowds at most destinations.

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Compare Rates

Always compare Booking.com, the hotel's own site, and specialist agents — rates vary significantly.